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KMID : 0364819870250010034
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Korean Journal of Microbiology
1987 Volume.25 No. 1 p.34 ~ p.39
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The Replication of Parvovirus KBSH DNA in the Embryonic Swine Kidney Cells
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Lee, S.W./이성욱
Kim, Y.S./Kang, H.S./김연수/강현삼
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Abstract
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1
To study the replication process of the single-stranded DNA parvovirus KBSH -isolated from normal human cell cultures-in actively dividing embryonic swine kidney cells, amount of the synthesized viral hemagglutinating(HA) antigen and the overall rate of viral double-stranded replicative form(RF) DNA synthesis were examined. The initiation of viral RF DNA synthesis and the decrease of host DNA synthesis rate in viral infected cells occurred almost same time at 15-16 hour post infection(PI). And the release of viral HA antigen to media followed at 24 hour PI, concurrently the overall rate of viral RF DNA synthesis reaching its maximum. Evidence is presented which indicates that successful performance of viral RF DNA replication requires proteins synthesized in viral infected cells at 10-14 hour PI.
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KEYWORD
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